Nipah Disease


Origin of name

From the village, Sungai Nipah, Malaysia, where the virus was isolated from the first human victim

Causal agent

Virus a paramyxovirus closely related to the Hendra virus

Age group

Weaners, growers and finishers and adults

Clinical signs


Mild to severe coughing. High morbidity but low mortality

Sows and boars

Moderate to severe respiratory signs with dyspnoea, convulsions and death. Death can occur within several hours.



Infection via oral route with incubation period of 14 to 16 days.

Dogs and flying foxes have been found to be seropositive

Post-mortem Lesions


Varying degrees of consolidation of the lungs, primarily the diaphragmatic lobes (prominently thickened interlobular septa). Kidneys show signs of congestion. Other organs normal



Virus isolation and serological



None, notifiable disease. Inform government vet with any suspicions

Common differentials


Actinobacillus pleuropneumonia. Haemophilus parasuis in adults

Zoonotic implications


Very fatal to man, out of 258 people infected 100 died

Mild to severe clinical signs, characterised by fever and headaches of varying severity. Patients become drowsy and disoriented leading to coma. Majority of patients developing coma die.

Incubation period in man one to three weeks