All elimination programmes hinge on the availability of negative pigs to purchase or that internal replacements will be negative

1	Depopulation and Repopulation
	Here all pigs, pig products and faecal contaminates must be removed from the farm, followed by fumigation and resting of the farm. The farm is then repopulated with animals negative to the pathogen. For this reason PMWS is still difficult until the causal pathogen is identified.
2	Hysterectomy and move piglets to a new farm
	A sow at the point of farrowing is euthanased and her uterus removed and placed in disinfectant and carried 20 metres from the euthanasia point. Here the piglets are removed from the uterus and immediately placed in a warm box and taken from the area. None reproductive or systemic diseases can be eliminated – Actinobacillus pleuropnuemoniae, Mycoplasma hyopneumoniae and Sarcoptes scabiei for examples.
3	Direct pathogen exposure
	All susceptable animals are exposed to the pathogen. The pathogen has no long term carrier status. The pathogen then dies out on the farm. New animals animals are negative to the pathogen. Enteric viruses – TGE and PED are classic pathogens that may be controlled. PRRSv has been controlled by the method combined with herd closure.
4	Vaccination
	All suscptable animals are vaccinated. The pathogen then dies out on the farm. Generally it is important to identifym vaccinated from wild/field pathogen infected animals. Aujeszky’s (PRV) is controlled by vaccination, combined with test and remove.
5	Segregated early weaning
	Segregated early weaning utilising maternal colostrum antibodies possibly combined with medication has proved effective at eliminating several pathogens, Mycoplasma hyopnuemoniae and PRRSv. Toxigenic Pasteurella multocida may be eliminated but will need vaccination control and very early removal of the piglets. APP has been eliminated but requires pre-day 8 weaning of the piglets.
6	Partial depopulation (Swiss Depop)
	Partial depopulation is where the susceptible population is removed and the pathogen is removed from the remaining adult stock. Mycoplasma hyopneumoniae or PRRSv are examples.
7	Test and remove
	All infected animals are identified and removed before they spread the pathogen to remaining susceptible animals. This can be very difficult to achieve. Aujeszky’s (PRV) combined with vaccination has been successfully eliminated. PRRSv has been eliminated by this method.
8	Herd Closure
	The pathogen dies out of the farm over time. Combined with vaccination and direct pathogen exposure, PRRSv and Swine Influenza has been eliminated by this method.
9	Medication Programmes
	The pathgen has to be susceptable to medication, viruses for example can not be eliminated. Sarcoptes scabiei (Mange) and Haematopinus suis (Lice) can be eliminated by avomectins. Tilmicosin or Tulathromycin has eliminated Mycoplasma hyopneumoniae especially when combined with segregated weaning and partial depopulation. Tiamulin may be effective in eliminating Brachyspira hyodyenteriae when combined with cleaning and partial depopulation.